MAPT and Alzheimer disease: Previous studies showed that treatment with an α1-AR antagonist, i.e., prazosin or doxazosin, could reduce the generation of Aβ in N2a cells, alleviate neuroinflammation, and prevent memory deficits in APP23 transgenic mice (Katsouri et al., 2013), as well as protecting hippocampal slices from Aβ neurotoxicity through prevention of GSK-3β activation and tau hyperphosphorylation in an in vitro model of AD (Coelho et al., 2019).