MAPT and Cognitive impairment: Ablation of the LC-NE system, in turn, further exacerbates Aβ and tau pathology and the resulting cognitive deficits (Chalermpalanupap et al., 2018; Jacobs et al., 2021) and neuroinflammation (Jardanhazi-Kurutz et al., 2011; Cao et al., 2021), setting up a vicious cycle.