A study further to test this hypothesis subjected an animal model of cognitive impairment induced by a high-fat diet to a treadmill running program (30 min/session, 5 sessions/week for 23 weeks at 40–50% VO2peak); activation of the β2-AR/cAMP/PKA pathway, increased expression of TRX-1 and BDNF, inhibition of microglial activation, decreased expression of inflammatory markers, and reduction of oxidative stress markers in the dentate gyrus of the hippocampus were observed (Han et al., 2019). This evidence concerns the gene ADRB2 and Cognitive impairment.