In AD brains, p62 accumulation occurs in pyramidal neurons as previously shown (Kuusisto et al., 2002) in both cortex (Figure 1E) and hippocampus including dentate gyrus (DG) (Figure 1F) and CA1 (Figure 1G) of AD brains (semi-quantified in Figures 1I,J), whereas no p62 accumulation was found in brains of non-demented individuals (Figures 1A–C). Here, SQSTM1 is linked to Alzheimer disease.