Significantly lower SBR in the SMDCS + group (1.28 ± 0.41) than that in the SMDCS – group (1.64 ± 0.38), and a high negative correlation coefficient of SMDCS with SBR (−0.45) indicated a good correlation of the novel tool with reducing dopamine transporter uptake in the striatal areas, which is currently the hallmark of brain imaging study for the diagnosis of DLB. Here, SLC6A3 is linked to Lewy body dementia.