FKBP5 and major depressive disorder: In a meta-analysis of the relationship among FKBP5 gene variation, ELS and depression/PTSD, it was found that those carrying T allele in the rs1360780 gene, C allele in the rs3800373 gene, or T allele in the rs9470080 gene had a higher risk of depression or PTSD after early trauma (Dackis et al., 2012).