TNF and cancer: For example, intravenous (IV) administration of inflammatory cytokines interleukin-1 (IL-1), tumor necrosis factor alpha (TNF-alpha), and interleukin-6 (IL-6)- all of which are upregulated during cancer progression- has been shown to induce sickness behavior (including sleep disruption) similar to those observed during infection in both mice and humans (Focà et al., 1983; Lesnikov et al., 1991; Ching et al., 2007).