Medina-Trillo et al. reported five rare heterozygous FOXC1 variants ((rs77888940, c.-429C>G; rs730882054, c.1134_144delCGGCGGCGCGG; rs35717904, c.∗734A>T; rs185790394, c.-244C>T; and rs79691946, c.∗454C>T) in 10 patients without a family history of glaucoma, and this indicated that FOXC1 variants may contribute to the formation of goniodysgenesis in PCG [62]. Here, FOXC1 is linked to glaucoma.