Because the stimulation of P2X7R expressed by CD4+ T cells has shown to promote the differentiation of CD4+ T cells into TH17 and TH1 profiles (Atarashi et al., 2008; Killeen et al., 2013; D’Addio et al., 2018), this might explain, at least in part, the promotion of the TH17 profile observed in children with COVID-19. This evidence concerns the gene CD4 and COVID-19.