TARDBP and amyotrophic lateral sclerosis: Recently, amyotrophic lateral sclerosis (ALS)- and frontotemporal dementia (FTD)-linked TAR DNA-binding protein 43 (TDP-43) inclusions have been shown to affect cAMP and Ca2+ signaling in astrocytes, most likely due to the downregulation of β2-adrenergic receptors leading to dysregulated astroglial metabolism and disease progression (Velebit et al., 2020).