TREM2 is a cell surface protein binding to phospholipids, phosphatidylserine, sulfatides, LPS and DNA, which is involved in amyloid β and apoptotic neuron clearance, as well as AD risk (Guerreiro et al., 2013; Jonsson et al., 2013; Wang et al., 2015; Krasemann et al., 2017). The gene discussed is TREM2; the disease is Alzheimer disease.