A study which tested the effect of blocking E-selectin and CXCR4 using GMI-127 and GMI-1359 in order to sensitize MM cells to chemotherapy, found that decreasing the expression of E-selectin, and thus CXCR-4 mediated adhesion and MM cells chemotaxis, made the tumor cells more sensitive to treatment in vivo [60]. This evidence concerns the gene CXCR4 and Miyoshi myopathy.