Lactate, commonly found in the microenvironment of aerobic glycolytic cancer (de la Cruz-López et al., 2019; Kim and DeBerardinis, 2019; Pérez-Tomás and Pérez-Guillén, 2020), was recently identified to enhance resistance to ferroptosis damage induced by ferroptosis inducers RSL3 and erastin when it is uptake into HCC cells through the monocarboxylate transporter 1 (MCT1). Here, MCAT is linked to hepatocellular carcinoma.