Acyl-CoA synthetase long-chain family member 4 (ACSL4), a ferroptosis-positive activating enzyme that esterifies free PUFA and binds to membrane phospholipids by LPCAT3, is considered a ferroptosis biomarker in hepatocellular carcinoma and has been proposed to be useful to predict the sensitivity of Sorafenib in HCC (Feng et al., 2021). The gene discussed is LPCAT3; the disease is hepatocellular carcinoma.