For example, the activation of the Ras-RAF-MEK-ERK pathway is necessary for Erastin-induced cell death in tumor cells harboring activating mutations in the RAS-RAF-MEK pathway (Xie et al., 2016) but not in acute myeloid leukemia where only inhibition of p38 and JNK was associated with resistance to Erastin-induced cell death (Yagoda et al., 2007; Yu et al., 2015) or in human pancreatic islet-like cells where p38 and JNK activation was necessary for Erastin induced ferroptosis to occur (Li and Leung, 2020) or to cold-induced ferroptosis in multiple cell lines (Hattori et al., 2017). Here, MAPK8 is linked to neoplasm.