Interesting, deletion of mediator complex component Med1 (Nakajima et al., 2013) or the SWI/SNF-like BAF complex catalytic subunit Brg1 (Xiong et al., 2013) also elicits HFSC exhaustion and alopecia phenotype, although in the case of BAF complex, its function is context dependent and regulates either stem cell expansion or differentiation based on which lineage is examined (Bao et al., 2013; Mardaryev et al., 2014). This evidence concerns the gene BANF1 and alopecia.