Specifically, gain-of-function mutations in Notch receptors NOTCH1 and NOTCH2, as well as increased expression of NOTCH1 and NOTCH3, are found in breast cancer (Lee et al., 2008; Yamaguchi et al., 2008; Robinson et al., 2011; Choy et al., 2017). This evidence concerns the gene NOTCH1 and breast carcinoma.