For instance, while OLM disruption was observed early in the degeneration process in Crb1rd8/rd8, Prph2+/307, and Pde6brd1/rd1 mutant mice, the Rho−/− mouse model of RP showed disruption of OLM only in late stages of the disease (Hippert et al., 2015). Here, RHO is linked to retinitis pigmentosa 1.