TGFB1 and neoplasm: Figure 1 shows that, in parallel with an accelerated tumor growth (Figures 1A–C), P2X7R null mice also show a generalized reduction of systemic pro-inflammatory cytokines (Figures 1D–I) as well as an increase of the immune suppressant TGF-β (Figure 1J). Notably, blood concentration of IL-6 (Figure 1F), IL-12 (Figure 1G), IL-17 (Figure 1H), and IFN-γ (Figure 1I) was strikingly decreased (more than halved), suggesting a substantial impairment of anti-tumoral immune responses. On the contrary, blood TGF-β levels were almost triplicated (Figure 1J).