Importantly, A2AR not only promotes the establishment of a pro-tumorigenic environment driving macrophage differentiation but also mediates the direct effects of eADO on tumor cells, as shown by the finding that in animal models, tumor cell A2AR promotes invasiveness, motility and proliferation (Beavis et al., 2013; Koszalka et al., 2016; Allard et al., 2019; Kamai et al., 2021). The gene discussed is ADORA2A; the disease is neoplasm.