Figure 3 shows a significantly higher intra-mass accumulation of VEGF in tumors growing in P2X7R-null mice than WT controls (Figure 3C). The high VEGF tumor levels were paralleled by an augmented expression of the endothelial marker CD31 (Figures 3D–F), indicating increased intratumor blood vessel formation. The gene discussed is VEGFA; the disease is neoplasm.