FGF23 and neoplasm: Although there was a lack of research on tumor-promoting effects of high expression of FGF-23, the important role of FGF/FGFR signaling in prostate cancer and paraneoplastic diseases mediated by FGF23 overexpression, such as hypophosphatemia, also suggested a link between FGF-23 and tumors (Lee et al., 2014).