In vitro experiments showed that bladder cancer cell line TSGH-8301 was more dispersed and separated from each other after stimulation with uremic toxin p-cresyl (P-CS), and indicated that ROS was a key signal for cell migration induced by P-CS which further induced bladder cancer cell migration and epithelial mesenchymal transition (EMT) through reactive oxygen species/Src/focal adhesion kinase (ROS/Src/FAK) signaling pathway (Peng et al., 2020). Here, PTK2 is linked to urinary bladder cancer.