TGFB1 and neoplasm: Current studies revealed that radiotherapy caused immunosuppressive effects in the tumor microenvironment due to the attraction of immunosuppressive cells such as regulatory T cells (Tregs) as well as because of the release of immunosuppressive cytokines (TGF-β and IL-10) and chemokines (Shevtsov et al., 2019; Sato et al., 2020).