MAPT and supranuclear palsy, progressive, 1: Grey and white matter degeneration of the thalamus is also a common finding in PSP15,17,67,68 and CBD.69,70 Thalamic degeneration was often described in relation to neurofibrillary tangle burden in PSP.66,71,72 Although we found moderate to severe tau burden particularly of the neuronal type in the thalamus, neither the severity of tau inclusions nor the lesion type appeared to be involved in the regional changes in volume or diffusivity.