MAPT and supranuclear palsy, progressive, 1: The distinction between neuronal and glial pathology is gaining more interest in the field of 4R tauopathies because of their different anatomical distribution, histopathology and pattern of spread.55–57 Recently, Kovacs et al. 55 found that neuronal loss in PSP correlated with total tau load only in regions where neuronal tau predominated (i.e., subcortical regions and brainstem) and not in cortical areas were astroglial tau were more abundant.