Microglial activation was found to parallel neurodegeneration in PSP and CBD, mostly in association with glial tau pathology.56,65,75 As previously mentioned, astrocytic pathology is capable of activating microglial genes in PSP.56 Still in PSP, Malpetti et al. 76 showed that baseline neuroinflammation, as measured by PET imaging using [11C]PK11195 ligand to trace microglial activation, showed correlation with regional atrophy and disease progression. The gene discussed is MAPT; the disease is supranuclear palsy, progressive, 1.