ACP5 and chronic kidney disease: This was confirmed for CTX by cosinor analyses in both CKD (p = 0.003) and controls (p = 0.002) with an acrophase at around 3 o'clock a.m. (Fig. 2), however, we were unable to find significant rhythmicity for P1NP, osteocalcin, BAP or TRAcP by cosinor analysis.