Overall, both CTX (p = 0.025) and osteocalcin (p = 0.007) were significantly higher in CKD compared to controls, while there was no overall difference between CKD and control for P1NP (p = 0.273), BAP (p = 0.449) or TRAcP (p = 0.438). Here, CYP27A1 is linked to chronic kidney disease.