IFNG and infarction: Intriguingly, natural killer (NK) cells can develop infarction by secreting IFN-γ in T- and B-cell-independent mechanisms and stimulate local inflammation by secreting pro-inflammatory cytokines such as IFN-γ, IL-17a, TNF-α, IL-1β, IL-6, IL-12, and ROS after middle cerebral artery occlusion (MCAO) [16].