Here, we also observed an apparent reduction in insulin sensitivity and an associated increase in fasting glucose levels between the two 5-year periods (2008–2012 vs. 2013–2017); these findings suggest that children with severe obesity are displaying increasing levels of impairment in glucose metabolism and possibly increased risk of progressing to type 2 diabetes. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.