In addition, the activities of check-point, tumor-infiltrating lymphocytes (TIL), chemokine C-C-Motif receptor (CCR), T-cell coinhibition, and type II interferon (IFN) response were markedly enhanced in the GDN subjects with low PRKAR2B expression or subjects with high TGFBI expression (Figure 7B). Here, TGFBI is linked to neoplasm.