In addition, the activities of check-point, tumor-infiltrating lymphocytes (TIL), chemokine C-C-Motif receptor (CCR), T-cell coinhibition, and type II interferon (IFN) response were markedly enhanced in the GDN subjects with low PRKAR2B expression or subjects with high TGFBI expression (Figure 7B). The gene discussed is PRKAR2B; the disease is neoplasm.