Li et al. (2021) reported that SNI reduced the expression of LAMB1, a major component of extracellular matrix in the ACC. Knockdown of LAMB1 in the ACC increased the release probability of neurotransmitters and led to abnormal postsynaptic spine remodeling, which in turn increased pain sensitivity and caused depression-like behaviors (Li et al., 2021). The gene discussed is LAMB1; the disease is major depressive disorder.