Of note, the gene sets of mitochondrial function, potassium channel regulator activity, extracellular matrix and Parkinson’s disease were also among the most significant ones regulated by SNI, indicating that the differences in transcriptomic changes after SNI in the mPFC versus the ACC are at least in part due to the distinct patterns of transcriptomes between these two regions at baseline. This evidence concerns the gene KCNA3 and Parkinson disease.