SNHG14 and Angelman syndrome: Of note, among the top transcripts upregulated by SNI in the mPFC of SNI female mice, Snhg14 encodes a long non-coding RNA that regulates the expression of ubiquitin protein ligase E3A (Ube3a), which is known to critically implicate in the social interaction dysfunction in Angelman’s syndrome (Stanurova et al., 2016; Chung et al., 2020).