In the present study, patients with SHROOM4 variants presented mainly generalized epilepsy, such as CAE, MAE, LGS, IGE, and those with partial seizures also had bilateral or generalized discharge or generalized seizures (Table 1 and Figure 1), potentially suggesting an association between SHROOM4 variants and generalized epilepsy. This evidence concerns the gene SHROOM4 and epilepsy with myoclonic atonic seizures.