SHROOM4 mutations have been demonstrated to be associated with Stocco dos Santos type of X-linked syndromic intellectual developmental disorder (SDSX; OMIM# 300166) (Froyen et al., 2007; Honda et al., 2010; Armanet et al., 2015; Farwell et al., 2015). Here, SHROOM4 is linked to X-linked intellectual disability, Stocco dos Santos type.