The current data demonstrated that two missense variants located in or closed to N-terminal PDZ domain were associated with generalized epilepsy; two missense variants located in the middle of protein were associated with ID, one of which was located near to C-terminal ASD2 domain and associated with epilepsy (Hagens et al., 2006; Farwell et al., 2015); missense variants located in or near to C-terminal ASD2 domain were associated with epilepsy with both focal and generalized seizures or discharges. Here, GATA4 is linked to Seizure.