Compared to the PCOS group, the PCOS+Rha group (Figures 2(b) and 2(c)) and the PCOS+Met group (Figure 2(b)–2(d)) reduced the number of cystic follicles with an increased thickness of the granulosa cell layer and a decrease in theca cells. The gene discussed is DHX9; the disease is polycystic ovary syndrome.