The levels of TGF-β1, TGF-βR1, and collagen I were obviously decreased (P < 0.01) and the levels of PPAR-γ were dramatically increased (P < 0.01) in the Rha-treated group and the Met-treated group in comparison with the PCOS group. The gene discussed is TGFB1; the disease is polycystic ovary syndrome.