HMGB1 and Sepsis: Hayashi et al. reported that the AN69ST membrane was not superior to the standard CRRT membrane in the treatment of sepsis due to acute panperitonitis [41], while Nakamura et al. suggested that AN69 had a strong adsorption capacity for high mobility group box 1 protein (HMGB1), a typical endogenous risk cytokine in sepsis [42].