Consistent with these observations, the results of gene set enrichment analyses of hallmark cancer pathways showed that cells were enriched for cellular damage response and that these signatures were retained in EVs for pathways such as MYC targets or androgen response (Figure 4D)(Gross et al., 2012; Miyamoto et al., 2015; Zhang and Wrana, 2014). The gene discussed is MYC; the disease is cancer.