CDH1 and cancer: Core fucosylationis also strongly linked to cancer cell invasion and metastasis.3 FUT8 is up-regulated in a large number of cancertypes,3 proposed to be due to at leastthree different mechanisms: (a) regulation of the expression of programmedcell death protein 1 (PD-1),4 (b) alterationof antibody-dependent cellular cytotoxicity (ADCC),5 and (c) regulation of transforming growth factor β1receptor (TFG-β),6 epidermal growthfactor (EGF) receptor,7 α3β1integrin,8 and E-cadherin.9 Based on this, FUT8 is considered a promising drug targetfor the treatment of a large variety of cancer types.