The administration of a single dose of cannabidiol (0.3, 1.0, 10, 20, 30, 40, and 80 mg/kg, i.p.), extracted from Cannabis sativa, before the LPS-induced ALI, decreased the migration of leukocytes into the lungs, albumin concentration in the BALF, production of pro-inflammatory cytokines and chemokines, and MPO activity in the lung tissue. Here, MPO is linked to acute respiratory distress syndrome.