The Portulaca oleracea extract (50, 100, and 200 mg/kg, p.o., 1 h before LPS injection) suppressed the LPS-induced rat ALI by decreasing IL-6, IL-β, TNF-α, TGF-β, and, PGE2 but increasing IL-10 levels. The gene discussed is TNF; the disease is acute respiratory distress syndrome.