The gallic acid (75, 150, and 300 mg/kg, for 3 weeks) in an animal model of BLM-induced PF reduced the inflammation process to some extent and could exert its effects through TGF β1/Smad2-signaling pathway and balancing NOX4/factor erythroid-2-related factor 2 (Nrf2) (38). This evidence concerns the gene SMAD2 and pemphigus foliaceus.