However, as we herein followed, the epigenetic role of diet demonstrates that it can alter several neuronal pathways (e.g., DAT, GR, HPA axis, neuronal membrane fluidity, neurotransmission, microbial neurotransmitters synthesis, neuronal damage, oxidative stress, and a long etcetera), that have been studied in the context of MDD pathophysiology, and new advances in clinical trials are demonstrating promising results in the reversion or attenuation of those epigenetic marks. The gene discussed is SLC6A3; the disease is major depressive disorder.