HP and irritable bowel syndrome: Intestinal mucosa damage can increase the Zonulin and DAO activity (32), and probiotics such as Bifidobacterium, Lactobacillus and Streptococcus (32), Bacillus coagulans, and Lactobacillus plantarum (7) can decrease the concentration of DAO and Zonulin, has been shown to be optimal for reducing inflammatory responses and bacterial translocation (33), LAB and L. casei DN-114 001 also reduced small bowel permeability in D-IBS (34, 35).