In addition, Fiaf has been found to be related to obesity and can regulate lipid metabolism in different tissues, while A. muciniphila and its related SCFA metabolites can induce the expression of Fiaf, inhibit the generation of low-density lipoprotein (LDL), and maintain lipid homeostasis and metabolism in intestinal and peripheral tissues (127). This evidence concerns the gene ANGPTL4 and obesity due to melanocortin 4 receptor deficiency.