In addition, some researchers have attempted to establish that the SCFA-GPR43-GLP-1 pathway in the intestinal tract relieves hyperglycemia and found that activating this pathway had a good effect on the gut microbiota disturbance induced by tacrolimus and glucose metabolism disorder caused by ecological disorders; it also reversed the change in butyrate concentration in the cecum and increased the expression level of GPR43 in intestinal crypts. The gene discussed is FFAR2; the disease is Hyperglycemia.