In CRF, the stimulation of the parathyroid glands by the imbalance of acid-base balance and various electrolyte metabolism disorders, as well as the presence of calcium and phosphorus metabolism disorders and active vitamin D deficiency in the middle and late stages of renal failure promote the secretion of PTH and induce the development of SHPT (13, 14). The gene discussed is PTH; the disease is Renal insufficiency.