CASP8 and pancreatic neoplasm: Among 159 necroptosis genes, 18 genes (SPATA2, AIFM1, SLC25A4, BCL2, SPATA2L, TYK2, SMPD1, STAT5B, SLC25A6, USP21, STAT4, VPS4A, RIPK1, PLA2G4C, IL33, CAMK2B, MAPK10, and BAX) were protective factors of pancreatic cancer prognosis, while 14 genes (TNFRSF10B, HSP90AA1, BIRC3, TNFRSF10A, CHMP4C, CASP8, FADD, CAPN2, GLUD1, PYGL, BIRC2, CAPN1, CHMP2B, and IFNA13) were risk factors of prognosis, as depicted in Figure 1C.