CD4 and cancer: In Figure 8, we noted that the necroptosis-relevant risk score presented a significantly positive correlation to the release of cancer cell antigens but displayed significantly negative correlations to recruiting of B cells, CD4 T cells, dendritic cell, macrophages, T cells, Th17 cells, Treg cells, and killing of cancer cells, indicative of the remarkable interactions of the necroptosis-relevant risk score with the cancer–immunity cycle.