CD274 and cancer: Moreover, they had prominent associations with tumorigenic pathways (p53 signaling pathway and cell senescence) and immune pathways (Th17 cell differentiation, PD-L1 expression, PD-1 checkpoint pathway in cancer, Th1 and Th2 cell differentiation, etc.), indicative of the critical roles of necroptosis-relevant genes in pancreatic cancer progression (Figure 4B).