In this study, control and SY5-containing (500 ppm) chow diets were fed for 4 months to rTg4510 mice, a mouse tauopathy model expressing human four-repeat tau with P301L mutation in the forebrain at levels 13-fold higher than endogenous mouse tau (Ramsden et al., 2005). The gene discussed is MAPT; the disease is tauopathy.