In type 2-high allergic asthma, IL-4 and IL-13 are involved in mucus production and goblet cell hyperplasia in lung tissue, airway hyperresponsiveness, eosinophil invasion into the lungs, and IgE over-production (Woodruff et al., 2009; Pavord et al., 2019). Here, IGHE is linked to allergic asthma.