TLR4 and arthritic joint disease: Despite the initial TLR4-dependence in male pain being suggested to be in the spinal compartment, intrathecal injections were performed, which also include the DRG (Wang et al., 2005) (spinal) TLR4 has also been demonstrated to mediate the transition to a persistent mechanical hypersensitivity after the resolution of inflammation in serum-transferred arthritis in male mice.