In addition to these, a recent report by Zou et al. (2021) found a relationship between the expression level of SREBP-1 in HCC tissues and the prognosis of HCC RFA, and used a novel small molecule inhibitor of SREBP-1 in combination with RFA to achieve a better anti-tumor effect on HCC (Trott and Olson, 2010). This evidence concerns the gene SREBF1 and hepatocellular carcinoma.