The transplantation of ApoE−/−/IKKε+/+ bone marrow to ApoE−/−/IKKε−/− mice prevented double knockout mice from developing HFD-induced obesity, and the inflammasome and inflammatory response in the adipose tissue were reduced (Patel et al., 2015). Here, APOE is linked to obesity due to melanocortin 4 receptor deficiency.