CD4 and neoplasm: According to the results of the Western blot, CTP significantly increased the levels of CD4, CD8, and IL-2, and reduced the levels of CTLA4 and PD-L1 in the tumor (Figure 5A), and CTLA4 and PD-1 in the spleen (Figure 5B) of ApcMin/+ mice; this underscored the pivotal role of IL-2 in the immune response.