Fibrosis-related genes include Col1a1, Acta2, Fn1, and Tgfb1 gene, and senescence-related genes composed of Cdkn2a, Tnf, Serpine1, Ccl2, Mmp10, and Mmp12 gene, all of which reflected the intensity of lung fibrosis and senescence events in lung tissue and pulmonary fibroblasts. This evidence concerns the gene MMP12 and pulmonary fibrosis.