EGFR and neoplasm: It has been reported that the EGFR is essential in physiological processes just like cell migration, cell multiplication, and cell-cycle control (Wilusz et al., 2009) and that the overexpression of EGFR-AS1 is enough to cause resisting tyrosine kinase inhibitors and the downregulation of EGFR-AS1 which can induce the continuous tumor regression of squamous cell carcinoma (Tan et al., 2017).