p62 predominantly coexisted with phosphorylated tau in the NFTs and neuropil threads in the frontal cortex of AD, tufted astrocytes and coiled bodies in the striatum of PSP, astrocytic plaques in the frontal cortex of CBD, and Pick bodies in the frontal cortex of PiD patients (Figure 1a, Table S1). This evidence concerns the gene MAPT and Alzheimer disease.