YAP1 and glioblastoma: In line with these results, we found a reduction in both proteins expression when GBM cells were subjected to simulated μG for 24 h, suggesting that the mechanical unloaded condition compromised GBM proliferation mechanism due to the inactivation of the mechanosensitive YAP-1 protein followed by a lack of anchoring points to the actin cytoskeleton thus a change in cell structural stability.