The risk variant with the most pronounced effect on the development and progression of NAFLD is the rs738409 C > G single nucleotide polymorphism of patatin-like phospholipase domain-containing 3 (PNPLA3), which encodes the I148M protein variant of PNPLA3, also known as adiponutrin, a protein involved in lipid remodeling [108]. Here, PNPLA3 is linked to metabolic dysfunction-associated steatotic liver disease.