RPE-derived IL-1α also serves as an alarmin that promotes the release of other pro-inflammatory cytokines and the production of nucleotide-binding domain, leucine-rich repeat, pyrin domain 3 (NLRP3) receptor protein, pro-caspase-1, and pro-IL-1β that are essential for the NLRP3 inflammasome activation seen in the eyes of both dry and wet AMD patients [14–16]. The gene discussed is NLRP3; the disease is wet macular degeneration.