However, it has been found that hippocampal neurons in neuron-specific Drp1-deficient T2DM mice exhibited marked mitochondrial dysfunction and synaptic damage, and higher levels of oxidative stress and neuroinflammation, which may be due to the fact that Drp1 knockdown inhibits mitochondrial fission and impairs the autophagy process [160]. Here, DNM1L is linked to type 2 diabetes mellitus.