In the hippocampal neurons of T2DM mice and PC12 cells cultured with high glucose, it was further found that promoting FUNDC1-mediated mitophagy can eliminate mitochondrial fragmentation caused by overactivated Drp1, reduce mitochondria-derived apoptosis, and thus alleviate diabetic cognitive impairment [161]. This evidence concerns the gene FUNDC1 and type 2 diabetes mellitus.