CD274 and neoplasm: Presently, various standardized IHC PD-L1 antibody assays (e.g. Dako 22C3, Dako 28–8 and Ventana SP-142) have been approved as companion diagnostics to predict treatment response to different ICIs in various other tumor types (pembrolizumab, nivolumab and atezolizumab) [7].