Bearing in mind the later-on diagnosed SDRPL, the two NOTCH2 VUS with VAF of 7% might have reflected an otherwise non-perceptible infiltration of the respective lymph node, as NOTCH2 mutations are among the most common genetic alterations in the closely related splenic MZL [30], although the exact identified variants have not been yet described. This evidence concerns the gene NOTCH2 and splenic diffuse red pulp small B-cell lymphoma.