EZH2 and diffuse large B-cell lymphoma: EZH2’s counterpart is the histone demethylase Ubiquitously Transcribed Tetratricopeptide Repeat on chromosome X (UTX) that specifically erases di- and tri-methylation of H3K27 [32], and newer data on DLBCL suspect suppressed UTX to be much more significant than EZH2 with respect to tri-methylation of H3K27 [33].