These include associations with two genes (GJB2 and SLC26A5) that cause recessive hearing loss, burden associations in seven genes (MYO6, COCH, TECTA, SIX1, CEACAM16, POU4F3, and EYA4) and single-variant associations in two genes (TBC1D24 and COL11A2) that cause autosomal dominant hearing loss (reviewed in Shearer et al.36). The gene discussed is SIX1; the disease is hearing loss disorder.